Adult plant resistance in maize to northern leaf spot is a feature of partial loss-of-function alleles of Hm1.

Adult plant resistance (APR) is an enigmatic phenomenon in which resistance genes are ineffective in protecting seedlings from disease but confer robust resistance at maturity. Maize has multiple cases in which genes confer APR to northern leaf spot, a lethal disease caused by Cochliobolus carbonum race 1 (CCR1). The first identified case of APR in maize is encoded by a hypomorphic allele, Hm1A, at the hm1 locus. In contrast, wild-type alleles of hm1 provide complete protection at all developmental stages and in every part of the maize plant. Hm1 encodes an NADPH-dependent reductase, which inactivates HC-toxin, a key virulence effector of CCR1. Cloning and characterization of Hm1A ruled out differential transcription or translation for its APR phenotype and identified an amino acid substitution that reduced HC-toxin reductase (HCTR) activity. The possibility of a causal relationship between the weak nature of Hm1A and its APR phenotype was confirmed by the generation of two new APR alleles of Hm1 by mutagenesis. The HCTRs encoded by these new APR alleles had undergone relatively conservative missense changes that partially reduced their enzymatic activity similar to HM1A. No difference in accumulation of HCTR was observed between adult and juvenile plants, suggesting that the susceptibility of seedlings derives from a greater need for HCTR activity, not reduced accumulation of the gene product. Conditions and treatments that altered the photosynthetic output of the host had a dramatic effect on resistance imparted by the APR alleles, demonstrating a link between the energetic or metabolic status of the host and disease resistance affected by HC-toxin catabolism by the APR alleles of HCTR.

A Case of Sparganosis lnfesting on the Human Epididymis / 대한비뇨기과학회지

Sparganum is parasite infesting principally in the cats or dogs, but many human reported. In Korea, the reported cases of human sparganosis are over 20 cases. However the urogenital infestation of sparganum is relatively rare, and none of any report of infestation in the epididymis is available. We experienced a case of the sparganum infesting on the epididymis which vas confused with the epididymitis on palpation.

Statistical Observation on Inpatient (1961-1965) / 대한비뇨기과학회지

A statistical survey was made on 729 inpatients during the period of 4 years and 9 months, 1961-1965, in the Department of Urology, The First Army Hospital, in reference to age distribution, monthly distribution on various diseases of the genitourinary tracts and operative procedures.The tables in the text represent the result of the observation and are summarized as follows: The majority of the patients (85%) was distributed between the ages 21 and 26. Of 729 in patients, there were 270 cases (37%) of genito-urinary tuberculosis, 84 cases (11.5%) of urinary calculus,69 cases of trauma and 60 cases of non-specific urinary tract infection. There were 379 operative procedures including 91 nephrectomies, and 108 epididiymectomies.